Mice, those despised pests that cause palpitations when they appear in kitchens, may hold the key to healing if a heart attack ensues. Researchers are using human stem cells to repair heart damage in mice.
If this latest attempt to repair damaged hearts in lab mice is as promising as researchers at Children’s Hospital of Pittsburgh believe, some day stem cells may be injected in humans to heal the devastation left by heart attacks.
While stem cells are widely-viewed as interchangeable, the researchers led by Johnny Huard, PhD, used a “novel population†of stem cells they discovered that is derived from human skeletal muscle tissue.
His team purified the special stem cells and transplanted them into mice with heart damage similar to that in human heart attack victims.
Dr. Huard claims remarkable healing properties for the transplanted “myoendothelial cells.†They repaired the injured muscle, stimulated the growth of new blood vessels in the heart and reduced scar tissue from the injury. This dramatically improving the function of the injured left ventricle.
Dr. Huard directs stem cell work at the John G. Rangos Sr. Research Center, a unit of the Children's Hospital of Pittsburgh, PA.
"This confirms our belief that this novel population of stem cells discovered in our laboratory holds tremendous promise for the future of regenerative medicine...
“The important benefit of our approach is that as a therapy, it would be an autologous transplant.
This means that for a patient who suffers a heart attack, we would take a muscle biopsy from his or her muscle, isolate and purify the myoendothelial cells, and re-inject them into the injured heart muscle, thereby avoiding any risk of rejection by introducing foreign cells."
The myoendothelial cells used in this study were more effective at repairing the injured cardiac muscle and reducing scar tissue than previous approaches that have used muscle cells known as myoblasts, according to Dr. Huard.
At six weeks after injection, the myoendothelial cell-injected hearts functioned at 40 to 50 percent more effectively compared with hearts that had been injected with myogenic cells (myoblasts). Source: Children’s Hospital of Pittsburgh.
Results of this study are published in the Dec. 2 issue of the Journal of the American College of Cardiology. See Phyorg.com for details, click HERE